Dexrabeprazole sodium is a proton pump inhibitor and used in Gastro-esophageal reflux disease, gastric and duodenal ulcers. A simple, precise and accurate method was developed and validated by using a simple solvent system for Dexrabeprazole sodium as bulk and in tablet dosage form. In the developed method distilled water was used as solvent. The λmax was determined to be 284nm. The procedure was validated as per ICH guidelines. The linearity range was 2-28µg/ml with correlation coefficient 0.999. The %recovery for Dexrabeprazole sodium was found to be 97.82% to 102.39%. Limit of detection and limit of quantification were found to be 0.061µg/ml and 0.184 µg/ml respectively. The method has been successfully used to analyze commercial solid dosage containing 10 mg of Dexrabeprazole sodium with good recovery.
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